Contrave bupropion hydrochloride 90 mg / naltrexone hydrochloride 8 mg (NB-890)





Generic Name: bupropion and naltrexone (bue PRO pee on and nal TREX own)
Brand Names: Contrave

What is Contrave?

Contrave contains a mix of bupropion and naltrexone. Bupropion is an upper drug that can likewise diminish craving. Naltrexone is generally given to hinder the impacts of opiates or liquor in individuals with habit issues. Naltrexone may likewise check yearning and sustenance desires.

Contrave is an anorexiant amd is utilized to help oversee weight in corpulent or overweight grown-ups with weight-related restorative issues. This solution is utilized together with eating routine and exercise.

Contrave won’t treat any weight-related medicinal condition, for example, hypertension, diabetes, or elevated cholesterol.

Contrave isn’t endorsed to treat misery or other mental conditions, or to enable you to stop smoking.

Vital data

You ought not utilize Contrave on the off chance that you have uncontrolled hypertension, seizures, a dietary issue, opioid dependence, on the off chance that you take opiate pharmaceutical or different types of bupropion, or in the event that you have all of a sudden quit utilizing liquor, seizure solution, or a narcotic.

Educate your specialist regarding all your present meds and any you begin or quit utilizing. Many medications can cooperate with bupropion and naltrexone, and a few medications ought not be utilized together.

Try not to utilize Contrave on the off chance that you are pregnant.

Some youngsters have considerations about suicide when initially taking bupropion. Remain alarm to changes in your mind-set or indications. Report any new or exacerbating manifestations to your specialist.

Try not to take Contrave on the off chance that you likewise take opiate prescription or different types of bupropion, (for example, Wellbutrin or Zyban), or in the event that you are experiencing withdrawal from liquor or medication compulsion.

Before taking this prescription

Try not to utilize Contrave on the off chance that you are pregnant. Weight reduction amid pregnancy can hurt an unborn infant, regardless of the possibility that you are overweight. Tell your specialist immediately on the off chance that you end up plainly pregnant amid treatment.

You ought not utilize Contrave on the off chance that you are oversensitive to bupropion or naltrexone, or on the off chance that you have:

  • untreated or uncontrolled hypertension;
  • a dietary problem (anorexia or bulimia);
  • a background marked by seizures;
  • opioid compulsion or withdrawal (or on the off chance that you take methadone or buprenorphine);
  • on the off chance that you take different types of bupropion (Wellbutrin, Aplenzin, Budeprion, Forfivo, Zyban, and others); or
  • on the off chance that you have all of a sudden quit utilizing liquor, seizure prescription, or a narcotic, for example, Xanax, Valium, Fiorinal, Klonopin, and others).

Try not to utilize a MAO inhibitor inside 14 days earlier or 14 days after you take Contrave. A hazardous medication communication could happen. MAO inhibitors incorporate isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, and tranylcypromine.

To ensure Contrave is ok for you, tell your specialist on the off chance that you have ever had:

  • discouragement, bipolar confusion, or psychological sickness;
  • self-destructive musings or activities;
  • head damage;
  • a tumor or disease in your mind or spinal rope;
  • diabetes or low glucose;
  • low sodium levels;
  • liver or kidney ailment;
  • coronary illness, hypertension, heart assault, or stroke; or
  • medicate habit, or on the off chance that you regularly drink a ton of liquor.

Some youngsters have considerations about suicide when initially taking bupropion. Your specialist should check your advance at normal visits. Your family or different parental figures ought to likewise be aware of changes in your inclination or side effects.

Bupropion and naltrexone can go into bosom drain and may hurt a nursing child. You ought not bosom nourish while utilizing this pharmaceutical.

Contrave isn’t endorsed for use by anybody more youthful than 18 years of age.

In what manner would it be a good idea for me to take Contrave?

Take Contrave precisely as endorsed by your specialist. Take after all headings on your medicine mark. Try not to utilize this medication in bigger or littler sums or for longer than suggested. Try not to pulverize, bite, or break the tablet. Gulp down it. Try not to take more than 2 tablets on the double.

Try not to bring Contrave with a high-fat dinner, or you might probably have a seizure.

In the event that you have to utilize opiate solution for any reason, (for example, torment, surgery, or treatment for medicate enslavement) you may need to quit taking Contrave for a brief timeframe. Take after your specialist’s dosing directions precisely.

Store Contrave at room temperature far from dampness and warmth.

In the event that you have not lost no less than 5% of your beginning weight following four months of treatment, Contrave may not be ideal for you.

Contrave dosing data

Normal Adult Dose of Contrave for Weight Loss:

Introductory measurements:

  • – Week 1: One tablet (8 mg naltrexone/90 mg bupropion) orally once in the morning; at that point
  • – Week 2: One tablet orally twice every day (once in the morning and once at night); at that point
  • – Week 3: Two tablets orally in the morning and one tablet orally at night

Support measurements: Week 4 and forward: Two tablets orally twice every day (morning and night)

Greatest measurements: Two tablets orally twice per day


  • – Discontinue treatment if a patient has not lost no less than 5% of pattern body weight following 12 weeks at the support dosage.
  • – The impact of this medication on cardiovascular horribleness and mortality has not been built up.
  • – The wellbeing and adequacy of this medication in blend with different items proposed for weight reduction, including professionally prescribed medications, over-the-counter medications, and natural arrangements, have not been set up.


A subordinate to a decreased calorie eat less carbs and expanded physical movement for unending weight administration in grown-ups with an underlying weight file (BMI) of:

  • – 30 kg/m2 or more prominent (stout) or
  • – 27 kg/m2 or more prominent (overweight) within the sight of no less than one weight-related comorbid condition (e.g., hypertension, sort 2 diabetes mellitus, or dyslipidemia)

What happens in the event that I miss a measurements?

Take the missed measurement when you recollect. Skirt the missed measurements in the event that it is nearly time for your next booked dosage. Try not to take additional prescription to make up the missed measurements.

Try not to take more than 4 tablets in 1 day.

What happens on the off chance that I overdose?

Look for crisis medicinal consideration or call the Poison Help line at 1-800-222-1222. An overdose of this medication can be lethal, particularly on the off chance that you likewise take an opiate (opioid drug).

What would it be a good idea for me to keep away from while taking Contrave?

Take after your specialist’s guidelines about any confinements on nourishment, drinks, or action. Try not to assume other weight reduction items or eating routine pills unless your specialist has instructed you to.

Try not to utilize opiate pharmaceutical, methadone, heroin, or other road drugs while you are taking Contrave. Doing as such could bring about perilous impacts, including trance like state and passing.

Drinking liquor with Contrave may expand your danger of seizures. In the event that you drink liquor frequently, chat with your specialist before changing the sum you drink. Bupropion can likewise cause seizures in a normal consumer who all of a sudden quits drinking.

Contrave reactions

Get crisis medicinal help on the off chance that you have indications of a hypersensitive response to Contrave: fever, swollen organs, mouth injuries, muscle or joint agony; hives, rash or tingling; chest torment, troublesome breathing; swelling of your face, lips, tongue, or throat.

A man administering to you should look for crisis restorative consideration on the off chance that you have moderate breathing with long delays, serious tiredness, or on the off chance that you are difficult to wake up.

Quit taking this drug and summon your specialist right in the event that you have:

  • a seizure (writhings);
  • obscured vision, exclusive focus, eye agony or swelling, or seeing radiances around lights;
  • changes in temperament or conduct – uneasiness, sadness, freeze assaults, inconvenience resting, tumult, musings about suicide or harming yourself;
  • a hyper scene – hustling contemplations, expanded vitality, irregular hazard taking conduct, extraordinary joy, being bad tempered or chatty;
  • liver issues – upper stomach torment, tiredness, dim pee, jaundice (yellowing of the skin or eyes);
  • expanded circulatory strain – extreme cerebral pain, obscured vision, beating in your neck or ears, uneasiness, nosebleed; or
  • serious skin response – fever, mouth or throat torment, consuming eyes, skin torment, red or purple rash that spreads and causes rankles and peeling.

More seasoned grown-ups might probably have certain symptoms.

Regular Contrave reactions may include:

  • queasiness, spewing, the runs, blockage;
  • cerebral pain, unsteadiness;
  • dry mouth; or
  • rest issues (sleep deprivation).

This isn’t an entire rundown of reactions and others may happen. Call your specialist for restorative counsel about reactions. You may report symptoms to FDA at 1-800-FDA-1088.

What different medications will influence Contrave?

When you begin or quit taking Contrave, your specialist may need to alter the measurements of different medications you go up against a normal premise.

Educate your specialist regarding all your present solutions and any you begin or quit utilizing. This incorporates remedy and over-the-counter medications, vitamins, and home grown items. Not every conceivable association are recorded in this medicine control.


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